Birth Interval Linked to Autism Risk
The risk for autism spectrum disorder (ASD) appears to be higher in children born after short or long interpregnancy intervals (IPIs), according to findings from the case-control Study to Explore Early Development
(SEED).
Specifically, ASD was more common among second- and later-born children who were conceived less than 18 months or at least 60 months after the mother's previous delivery. The correlation appeared to strengthen after a 60-month interval. IPI was not associated with other developmental disorders. Lead author Laura A. Schieve, PhD, an epidemiologist from the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention in Atlanta, Georgia, and colleagues publishedresults from the SEED cohort online November 22 in Autism Research. SEED was established in 2007 at six sites across the United States to study the effect of preconception and prenatal factors on ASD risk. After adjusting for sociodemographic factors, the adjusted odds ratio for ASD among term births was 1.5 (95% confidence interval [CI], 1.1 - 2.2) for those with a shorter than 18-month interval and 1.5 (95% CI, 0.99 - 2.4) for those with an interval of 60 months or more.
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